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Selected Peer-Reviewed Publications

1. Tissue - and site-specific DNA recombination in transgenic mice.   Orban, P.C., Chui, D., and Marth, J.D.  Proc. Natl. Acad. Sci. USA 89, 6861-6865(1992).  

 

2. Deletion of the DNA polymerase beta gene in T cells using tissue-specific gene targeting.  Gu, H., Marth, J.D., Orban, P.C., Mossmann, H., and Rajewsky, K.  Science 265, 103-106(1994). 

3. T cell-specific deletion of a polypeptide N-acetylgalactosaminyltransferase gene by site-directed recombination.   Hennet, T., Hagen, F.K., Tabak, L.A., and Marth, J.D.  Proc. Natl. Acad. Sci. USA 92, 12070-12074(1995). 

 

4. Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis.  Chui, D., Oh-Eda, M., Liao, Y.F., Panneerselvam, K., Lal, A., Marek, K.W., Freeze, H.H., Moremen, K.W., Fukuda, M.N., and Marth, J.D.   Cell 90, 157-167(1997). 

5. Immune regulation by the ST6Gal sialyltransferase.   Hennet, T., Chui, D., Paulson, J.C., and Marth, J.D.   Proc. Natl. Acad. Sci. USA 95, 4504-4509(1998). 

6. Core 2 O-glycan biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.  Ellies, L.G., Tsuboi, S., Petryniak, B., Lowe, J.B., Fukuda, M., and Marth, J.D.  Immunity 9, 881-890(1998). 

7. The ST3Gal-I sialyltransferase controls CD8+ T cell homeostasis by modulating O-glycan biosynthesis.   Priatel, J.J., Chui, D., Hiraoka, N., Simmons, C.J.T., Richardson, K.B., Page, D.M., Fukuda, M., Varki, N.M., and Marth, J.D. Immunity 12, 273-283(2000). 

8. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.  Shafi, R., Iyler, S.P.N., O’Donnell, N., Ellies, L.G., Marek, K.W., Chui, D., Hart, G.W., and Marth, J.D.  Proc. Natl. Acad. Sci. USA 97, 5735-5739(2000). 

9. Genetic re-modeling of protein glycosylation in vivo induces autoimmune disease.  Chui, D., Sellakumar, G., Green, R.S., Sutton-Smith, M., McQuistan, T., Marek, K.W., Morris, H.R., Dell, A., and Marth, J.D.  Proc. Natl. Acad. Sci. USA 98, 1142-1147(2001). 

10. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.  Ellies, L.E., D. Ditto, D., Levy, G.G., Wahrenbock, M., Ginsburg, D., Varki, A., Le, D., and Marth, J.D.  Proc. Natl. Acad.Sci. USA 99, 10042-10047(2002). 

11. Dietary and genetic control of glucose transporter glycosylation promotes insulin secretion in suppressing diabetes.  Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., and Marth, J.D.  Cell 123, 1307-1321(2005). 

 

12. ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.  Grewal, P.K., Boton, M., Rameriz, K., Collins, B.E., Chui, D., Paulson, J.C., and Marth, J.D.  Mol. Cell. Biol. 26, 4970-4981(2006). 

13. Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.  Green, R.S., Stone, E.L., Tenno, M., Lehtonen, E., Farquhar, M.G., and Marth, J.D.  Immunity 27, 308-320(2007). 

14. The Ashwell receptor mitigates the lethal coagulopathy of sepsis.  Grewal, P.K., Uchiyama, S., Ditto, D., Varki, N., Le, D.T., Nizet, V., and Marth, J.D.  Nat. Med., 14, 648-655(2008). NIHMSID: NIHMS183221

15. Pathway to diet- and obesity-associated diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.  Ohtsubo, K., Chen, M.Z., Olefsky, J.M., and Marth, J.D.   Nat. Med., 17, 1067-1075(2011).