Hideaki Tahara


Selected Publication :  

1.   Fibroblasts genetically engineered to secrete interleukin-12 can suppress tumor growth and induce anti-tumor immunity to a murine melanoma in vivo.  Tahara, H, Lotze, MT et al.  Cancer Research 54: 182-189, 1994.

2.   Effective eradication of established murine tumors with interleukin 12 (IL-12) gene therapy using a polycistronic retroviral vector.  Tahara, H, Zitvogel, L, Lotze, MT et al.  J. Immunol. 154: 6466-6474, 1995.

3.   Viral interleukin 10 (vIL-10), the human herpes virus-4 cellular IL-10 (cIL-10) homologue, induces local anergy to allogeneic and syngeneic tumors.   Suzuki, T, Tahara, H et al. J. Exp. Med. 182:477-486, 1995.

4.   Phase I evaluation of intravenous recombinant human interleukin-12 (rhIL-12) in patients with advanced malignancies.  Atkins, BA, Tahara, H, Sherman, ML et al. Clin. Cancer Res. 3: 409-417, 1997.

5.   Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12.  Nishioka, Y, Tahara, H et al.  Cancer Res 59:4035-41, 1999.

6.   Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a Phase I study.  Kang, WK, Tahara, T, Lotze, MT and Park, CH. Human Gene Therapy 12:671-684, 2001.

7.   Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings.  Tani K, Tahara H, Asano S et al.  Mol Ther. 10:799-816, 2004.

8.   Systemic Administration of IL-23 Induces Potent Anti-tumor Immunity Primarily Mediated through Th1-type Response in Association with the Endogenously Expressed IL-12.   Kaiga T, Sato M, Kaneda H, Iwakura Y, Takayama T, and Tahara H. J Immunol 178:7571-80, 2007

9.   Milk Fat Globule EGF-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms.  Jinushi M, Tahara H et al.  J Exp. Med. 206:1317-1326,2009

10.  Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.   Jinushi M, Tahara H et al. Proc Natl Acad Sci U S A. 108:12425-30. 2011