Motoharu Seiki


MT1-MMP symposium on November 30, 2012


Selected Publication :  

1. Structure of the region of the replication origin of the Bacillus subtilis chromosome.   Seiki, M., Ogasawara, N., and Yoshikawa, H. Nature 281, 699-701(1979). 

2. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.  Seiki, M., Hattori, S., Hirayama, Y., and Yoshida, M.  Proc Natl Acad Sci U S A 80, 3618-3622(1983).

3. Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells.   Seiki, M., Eddy, R., Shows, T. B., and Yoshida, M.  Nature 309, 640-642(1984). 

4. Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.  Seiki, M., Hikikoshi, A., Taniguchi, T., and Yoshida, M. Science 228, 1532-1534(1985).  

5. Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.   Fujii, M., Tsuchiya, H., Chuhjo, T., Akizawa, T., and Seiki, M. Genes Dev 6, 2066-2076.S A 85, 7124-7128(1992). 

6. A matrix metalloproteinase expressed on the surface of invasive tumour cells.   Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M. Nature 370, 61-65(1994). 

7. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.  Itoh, Y., Takamura, A., Ito, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T., and Seiki, M. Embo J 20, 4782-4793(2001).  


8. Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase.  Sakamoto, T., D. Niiya, and M. Seiki.  J Biol Chem, 286(16), 14691-704(2011).

9. Network Analysis of the Focal Adhesion to Invadopodia Transition indentifies a PI3K-PKCa Invasive Signaling Axis.  Hoshino D, Jourquin J, Emmons SW, Miller T, Goldgof M, Costello K, Tyson DR, Brown B, Lu Y, Prasad NK, Zhang B, Mills GB, Yarbrough WG, Quaranta V, Seiki M, Weaver AM.  Sci Signal. Sep 11;5(241):ra66(2012).